Berberine has been reported to interfere with normal liver function in infants, raising a concern that it might worsen jaundice.10 For this reason, berberine-containing plants, including barberry, goldenseal, and Oregon grape should be used with caution during pregnancy and breast-feeding. Strong standardized extracts may cause stomach upset and should be used for no more than two weeks continuously. Other symptoms of excessive berberine intake include lethargy, nose bleed, skin and eye irritation, and kidney irritation.11
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.