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Lomotil®/Lonox®

Pronounced

"dye-fen-OX-ill-ate/AT-trow-peen"

Common brand names:

Lomotil

Uses

This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Diphenoxylate is similar to opioid pain relievers, but it acts mainly to slow the gut. Atropine belongs to a class of drugs known as anticholinergics, which help to dry up body fluids and also slow gut movement.

This medication should not be used to treat diarrhea caused by certain types of infection (such as C. difficile-associated diarrhea following antibiotic therapy). Talk to your doctor for more details.

This medication is not recommended for use in children younger than 6 years due to an increased risk of serious side effects (such as breathing problems).

How to Use This Medication

Take this medication by mouth as directed by your doctor, usually 4 times a day. The dosage is based on your medical condition and response to treatment. Children's dosage is also based on weight. If you need to continue treatment once your diarrhea is controlled, your doctor may direct you to lower your dosage. Do not increase your dose, take it more often, or use it for longer than prescribed.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

It is important that you drink the proper amount of fluids and electrolytes to prevent dehydration. Tell your doctor right away if you develop signs of dehydration (such as extreme thirst, decreased urination, muscle cramps, weakness, fainting). You may also need to change to a bland diet during this time to reduce irritation to your stomach/intestines. Consult your doctor or pharmacist for more information.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as stomach cramps, nausea, vomiting). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used this medication for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Inform your doctor if your condition does not improve after 2 days.

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

This information is intended only for residents of the United States. Products sold under the same brand names in other countries may contain different ingredients.

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Information expires December 2025.