Also indexed as:Beta Hydroxy-Beta-Methylbutyrate
HMB: Main Image

HMB (beta hydroxy-beta-methylbutyrate) is a metabolite of the essential amino acid leucine (one of the branched-chain amino acids).

  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Used for AmountWhy
High Cholesterol
3 grams daily2 stars[2 stars]
Supplementing with HMB, or beta-hydroxy-beta-methylbutyrate, has been reported to lower total and LDL-cholesterol levels.
HIV and AIDS Support and Preservation of Lean Body Mass

(Arginine, Glutamine)
1.5 grams of HMB, 7 grams of L-glutamine, and 7 grams of L-arginine twice per day2 stars[2 stars]
The combination of glutamine, arginine, and HMB may prevent loss of lean body mass in people with AIDS-associated wasting.
Athletic Performance and Improving Body Composition with Strength Training in Untrained People
3 grams daily1 star[1 star]
HMB, a breakdown product of an essential branched-chain amino acid, has a role in protein synthesis and might, therefore, improve muscle growth and overall body composition. Research suggests it might be effective only when combined with an exercise program in people who are not already highly trained athletes.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.