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Crizanlizumab is used by people with sickle cell disease to reduce the number of painful crises caused by the disease. It works by attaching to a certain substance in your body (P-selectin) and preventing blood cells from sticking together. Crizanlizumab belongs to a class of drugs known as monoclonal antibodies.

How to Use This Medication

Read the Patient Information Leaflet if available from your pharmacist before you start using crizanlizumab and each time you get an infusion. If you have any questions, ask your doctor or pharmacist.

This medication is given by a health care professional. It is given as directed by your doctor on a treatment schedule. It is injected slowly into a vein usually over 30 minutes. The first 2 infusions are usually given 2 weeks apart. After that, an infusion is usually given every 4 weeks. Follow your doctor's treatment schedule.

Infusion reactions may happen while you are receiving this medication and for up to 24 hours after treatment. Tell your doctor or nurse right away if you have symptoms such as pain, headache, dizziness, fever, chills, shivering, nausea, vomiting, diarrhea, itching, or trouble breathing. Your doctor may slow down or stop your treatment for some time if you have infusion reactions. Your doctor may also prescribe other medications (such as acetaminophen, nonsteroidal anti-inflammatory drugs-NSAIDs, antihistamines) before each treatment to help prevent these side effects. Carefully follow your doctor's directions for all of your medications.

The dosage and treatment schedule are based on your medical condition, weight, and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive the medication.

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Information expires December 2024.