Before taking neomycin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (such as tobramycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: hearing problems (including deafness, decreased hearing), intestinal problems (including blockage, swelling, ulcers), kidney problems, myasthenia gravis, Parkinson's disease.

High doses or longer use of neomycin may cause your body to not properly absorb some foods, nutrients (such as iron, Vitamins A and B-12), and drugs (such as digoxin, warfarin). Consult your doctor for more details.

Neomycin may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using neomycin before having any immunizations/vaccinations.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Newborn and premature babies may be more sensitive to the side effects of this drug, especially hearing problems.

This medication is not recommended for use during pregnancy. Although there have been reports of harm in babies born to women using similar drugs, the risk for harm may not be the same with this drug. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. However, many doctors consider breastfeeding safe while using this medication. Consult your doctor before breastfeeding.