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St. John’s Wort

Also indexed as:Hypericum perforatum, Saint John’s Wort, St. John's Wort
St. John’s Wort: Main Image© Steven Foster

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Botanical names:
Hypericum perforatum

Interactions with Supplements, Foods, & Other Compounds

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.11 Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

Interactions with Medicines

Certain medicines interact with this supplement.

What Are Drug Interactions
Types of interactions:beneficial= Beneficialadverse= Adversecheck= Check
dnicon_BeneficialReplenish Depleted Nutrients

none

dnicon_BeneficialReduce Side Effects

none

dnicon_BeneficialSupport Medicine

none

dnicon_AvoidReduces Effectiveness
Amprenavir
Atazanavir
Atazanavir-Cobicistat
Atorvastatin
Cyclosporine
Digoxin
Fosamprenavir
Indinavir
Ketamine
Lovastatin
Nelfinavir
Omeprazole
Ritonavir
Saquinavir
Simvastatin
Theophylline
Warfarin
Zolpidem
dnicon_AvoidPotential Negative Interaction
Alprazolam
Amitriptyline
Amoxapine
Chlordiazepoxide
Clomipramine
Clonazepam
Desipramine
Desogestrel-Ethinyl Estradiol
Diazepam
Doxepin
Estazolam
Ethinyl Estradiol and Levonorgestrel
Ethinyl Estradiol and Norethindrone
Ethinyl Estradiol and Norgestimate
Ethinyl Estradiol and Norgestrel
Fluvoxamine
Imipramine Pamoate
Levonorgestrel
Levonorgestrel-Ethinyl Estrad
Lorazepam
Mestranol and Norethindrone
Nefazodone
Norgestimate-Ethinyl Estradiol
Nortriptyline
Paroxetine
Paroxetine Mesylate
Phenelzine
Protriptyline
Sertraline
Temazepam
Trazodone
Trimipramine
Venlafaxine
dnicon_CheckExplanation Required
Fexofenadine
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.
References

Copyright © 2025 TraceGains, Inc. All rights reserved.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.