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Peginterferon Alfa-2a

Pronounced

"peg-in-ter-FEER-on alfa"

Common brand names:

Pegasys

Uses

Peginterferon alfa-2a is used alone or in combination with other medications to treat chronic hepatitis B and chronic hepatitis C, viral infections of the liver. It works by decreasing the amount of hepatitis virus in the body and helps your body's natural defense (immune system) fight the infection. Chronic hepatitis infection can lead to serious liver damage (cirrhosis) and liver cancer.

It is not known if peginterferon can cure hepatitis B or hepatitis C infections or can prevent you from passing the virus to others. Practice "safer sex" (such as the use of latex condoms) to lower the risk of passing the virus to others.

How to Use This Medication

Read the Medication Guide and Instructions for Use provided by your pharmacist before you start using peginterferon alfa-2a and each time you get a refill. Ask your health care professional how to prepare and use this medication. If you have any questions, ask your doctor or pharmacist.

Inject this medication under the skin as directed by your doctor, usually once every week. The injection is given in the abdomen or thigh. Do not inject near the belly button or at the waistline. The dosage is based on your medical condition, lab tests, and response to treatment. Children's dosage is also based on body size.

For a more comfortable injection, take the medication out of the refrigerator and let it warm to room temperature as directed in the Instructions for Use. Do not warm up this medication any other way (for example, do not heat it in the microwave or place it in hot water). Do not shake this medication. Before using, check this product for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the skin you are going to inject into (the injection site) with rubbing alcohol. Change the injection site each time to lessen injury under the skin. To lessen bruising, do not rub the injection site after a shot. Learn how to store and discard medical supplies safely.

Use this medication regularly to get the most benefit from it. To help you remember, use it at about the same time on the same day each week.

Drink plenty of fluids while using this medication unless your doctor directs you otherwise.

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

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Information expires December 2025.